SU14813 maleate ( SU-14813 maleate;SU 14813 maleate )

产品货号. M16168 CAS No. 849643-15-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SU14813 maleate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS.
产品描述

A broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS; shows poor activity for EGFR and c-Met in biochemical assays; inhibits VEGFR-2, PDGFR-β, and KIT phosphorylation in porcine aorta endothelial cells with IC50 of 5.2, 9.9, and 11.2 nM respectively; active in xenograft tumor models.Breast Cancer Phase 2 Discontinued
同义词

SU-14813 maleate;SU 14813 maleate
通路

Angiogenesis
靶点

VEGFR
受体

VEGFR
研究领域

Cancer
适应症

Breast Cancer

CAS Number

849643-15-8
分子量

558.56
分子式

C27H31FN4O8
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

CC1=C(NC(=C1C(=O)NCC(CN2CCOCC2)O)C)C=C3C4=C(C=CC(=C4)F)NC3=O.C(=CC(=O)O)C(=O)O
化学全称

1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-, (2Z)-2-butenedioate (1:1)

1. Patyna S, et al. Mol Cancer Ther. 2006 Jul;5(7):1774-82.
2. Hu-Lowe D, et al. Mol Cancer Ther. 2011 Nov;10(11):2015.

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